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December 8, 2025Blood

Evolution of Multiple Myeloma from a Genomic Perspective

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Authors

FMFrancesco MauraMSMehmet Samur

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Overview

Review reveals genetic predisposition and positive selection drive multiple myeloma progression, highlighting complex interactions.

Key Points

  • Genetic predisposition plays a critical role in evolving multiple myeloma from precursor conditions, impacting disease risk.
  • Key early genomic events like positive selection significantly influence the transformation from smoldering multiple myeloma to symptomatic disease.
  • Observational analysis highlights interactions between genetics and environmental factors, underscoring their relevance in myelomagenesis.
  • Integrating genomic data with immune profiling may improve identification of patients at high risk for multiple myeloma.

Cite This Study

Maura et al. (2025) studied this question.

synapsesocial.com/papers/694020d72d562116f28fa681https://doi.org/10.1182/blood.2024026313
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  2. 2Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial2025 · 19 citations
  3. 3The somatic mutation landscape of normal gastric epithelium2025 · 48 citations