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August 25, 2025Frontiers in EndocrinologyOpen Access

Profiling the metabolome of adenomyosis-associated infertility patients to predict the pregnancy outcome of frozen embryo transfer

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Authors

WZWen ZhangYCYidong ChenBHBing Han

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Overview

Prospective cohort study identifies key metabolites impacting pregnancy outcomes in adenomyosis patients undergoing frozen embryo transfer, suggesting harm and benefit indicators.

Key Points

  • A panel of 5 metabolites plus age effectively predicts pregnancy outcomes in adenomyosis patients.
  • The area under the curve was 0.879 in the ADM-Success vs. ADM-Fail comparison, indicating high predictive power.
  • Metabolomic analysis utilized ultrahigh-performance liquid chromatography-tandem mass spectrometry to evaluate blood samples.
  • Distinct plasma metabolic profiles were observed between adenomyosis patients and control subjects, suggesting diagnostic potential.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af5d5dad7bf08b1eae0470https://doi.org/10.3389/fendo.2025.1625638
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