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August 25, 2025Open Access

Tobacco Consumption and Maternal Age as Potential Risk Factors for Non-Syndromic Cleft Palate: A Cross-Sectional Study in Southeastern Iran

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Authors

AKAmir Hossein KhazaeiKermanshah University of Medical SciencesFKFatemeh KeikhaeeAPAbolfazl PayandehZahedan University of Medical Sciences

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Implication

Cross-sectional study identifies maternal tobacco use and age as key risk factors for non-syndromic cleft palate in southeastern Iran.

Key Points

  • Tobacco use during the first trimester significantly increases the odds of cleft palate, with a 2.12-fold higher risk.
  • Among 421 individuals, the most common type was cleft lip and palate at 58.4%, highlighting prevalent conditions in the population.
  • Logistic regression analysis confirmed maternal age of 35 years or older boosts cleft palate occurrence, indicating the need for preventive measures.
  • Enhancing prenatal care strategies for women, especially those over 35 or using tobacco, may reduce cleft incidence effectively.

Cite This Study

Khazaei et al. (2025) studied this question.

synapsesocial.com/papers/68af5d5dad7bf08b1eae063chttps://doi.org/10.21203/rs.3.rs-5894135/v1
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Also Consider

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  1. 1The Prevalence and Patterns of Consanguineous Marriages and Associated Factors in Southeast of Iran2024 · 6 citations
  2. 2Epidemiological and Spatiotemporal Descriptive Analysis of Patients with Nonsyndromic Cleft Lip and/or Palate: A 12‐Year Retrospective Study in Southern Iran2023 · 8 citations
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