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August 23, 2025CancersOpen Access

Molecular and Clinicopathological Profiling of Clear Cell Renal Cell Carcinoma with Rhabdoid Features: An Integrative Pathway-Based Stratification Approach

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This analysis uncovers molecular subgroups in clear cell renal cell carcinoma, suggesting unique therapeutic vulnerabilities.

Molecular subgroups of clear cell renal cell carcinoma were identified, revealing distinct biological characteristics based on integrated profiling.
Among 17 tumors studied, 100% displayed histological features common to clear cell renal cell carcinoma with significant rhabdoid differentiation.
Assessment included histomorphologic evaluation and next-generation sequencing to better define the tumor landscape.
Pathway-specific stratification may guide precision oncology and inform clinical trial design based on molecular heterogeneity.

Lu et al. (2025) studied this question.

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