This method demonstrates effective halogenation and deuteration in gem-difluoroallenes, indicating broad applicability for α-functionalization.
A practical and highly stereoselective approach for the synthesis of α-functionalized trifluoromethylated alkenes has been developed, enabling the incorporation of deuterium, halogen, or chalcogen atoms. The method accommodates a wide range of substrates and delivers the desired products in good yields with excellent E/Z selectivity. The reaction proceeds through a vinyl silver intermediate, formed via AgF addition to gem-difluoroallenes. Control experiments underscore the essential role of the gem-difluoro group in activating the α-carbon to initiate the reaction.
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Sathish et al. (2025) studied this question.
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