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This research aims to develop a method for synthesizing difluoroalkenes with complex carbon centers.

Pd-Catalyzed Regioselective Arylation of gem -Difluoroallenes: Access to Tertiary and Quaternary Center-Tethered Difluoroalkenes

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Pd-catalyzed arylation produces difluoroalkenes in a rapid and selective manner, indicating a novel synthetic route.

This research aims to develop a method for synthesizing difluoroalkenes with complex carbon centers.
Pd-catalyzed protoarylation of gem-difluoroallenes with arylboronic acids
Conducted under mild, base-free conditions using water as an additive
Facilitated deuterium incorporation from D2O
Achieved good to excellent yields of gem-difluoroalkenes bearing tertiary and quaternary centers
Demonstrated enantioinduction potential in preliminary asymmetric experiments
Showed significant roles for the gem-difluoro group and water in the reaction mechanism

Jain et al. (2026) studied this question.

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