Photomediated C‒H Trifluoromethoxylations Enabled by Bis(trifluoromethyl)peroxide

Kamar Shakeri; Merlin Kleoff; Paul Golz; Thomas Drews; Manuela Weber; Sebastian Riedel; Mathias Christmann

doi:10.1039/d5sc04945h

January 1, 2025Chemical ScienceOpen Access

Photomediated C‒H Trifluoromethoxylations Enabled by Bis(trifluoromethyl)peroxide

View Full Paper

Ask AI

Bookmark

Share

Key Points

Trifluoromethoxylation of non-activated C‒H bonds occurs under catalyst-free conditions, enhancing synthetic versatility.
Key reagent bis(trifluoromethyl)peroxide demonstrates efficient reactivity in a broad range of C‒H bonds.
The method employs light-driven reactions in acetone, making it a potentially greener alternative for organic synthesis.
The findings may expand the applications of C‒H functionalization in creating complex organic molecules.

Implication

A photomediated method enables trifluoromethoxylation of C‒H bonds in various substrates, suggesting practical applications in organic chemistry.

Abstract

We describe a photomediated protocol for the trifluoromethoxylation of benzylic, aldehydic, and non-activated C‒H bonds, using bis(trifluoromethyl)peroxide (BTMP, (F3CO)2) as the key reagent. Under catalyst-free conditions in acetone, this reaction...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Shakeri et al. (2025) studied this question.

synapsesocial.com/papers/68af5d6fad7bf08b1eae1167 https://doi.org/10.1039/d5sc04945h

View Full Paper

Ask AI

Bookmark

Share

Photomediated C‒H Trifluoromethoxylations Enabled by Bis(trifluoromethyl)peroxide

Key Points

Implication

Abstract

Discussion

Cite This Study

Photomediated C‒H Trifluoromethoxylations Enabled by Bis(trifluoromethyl)peroxide

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading