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August 22, 2025Open Access

Small Extracellular Vesicles Secreted by Cisplatin-Resistant Neuroblastoma Cells Increase Lactate Secretion and Alter Metabolic Pathways in Primary Human Umbilical Vein Endothelial Cells (HUVECs)

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Authors

TFThomas F. FrawleyLMLin MaMAMuhammad Zainul Arifin

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Overview

This analysis demonstrates how small extracellular vesicles from cisplatin-resistant neuroblastoma cells alter metabolic pathways in HUVECs, suggesting a mechanistic role in chemoresistance and angiogenesis.

Key Points

  • Increased lactate secretion in HUVECs indicates altered metabolism due to sEVs from cisplatin-resistant cells.
  • sEVs from drug-resistant neuroblastoma cells enhanced oxygen consumption and angiogenic processes in recipient endothelial cells.
  • In vitro assessments reveal HUVEC proliferation and tubule formation are influenced by the metabolic shifts caused by sEVs.
  • Results suggest targeting sEVs may provide new therapeutic strategies against neuroblastoma chemoresistance and angiogenesis.

Cite This Study

Frawley et al. (2025) studied this question.

synapsesocial.com/papers/68af5d75ad7bf08b1eae1385https://doi.org/10.20944/preprints202508.1630.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small Extracellular Vesicles Secreted by Cisplatin-Resistant Neuroblastoma Cells Increase Lactate Secretion and Alter Metabolic Pathways in Primary Human Umbilical Vein Endothelial Cells (HUVECs)2025 · 2 citations
  2. 2Differential Effects of Mesenchymal Stem Cell- and Natural Killer Cell-Derived Extracellular Vesicles on Cisplatin Responsiveness in Endometrial Cancer Cells2026
  3. 3Chemo‐small extracellular vesicles released in cisplatin‐resistance ovarian cancer cells are regulated by the lysosomal function2024 · 6 citations
  4. 4Red blood cell-derived extracellular vesicles enable cisplatin and cetuximab combined therapy against triple-negative breast cancer2026
  5. 5Abstract A113: Extracellular vesicles derived from enriched ovarian cancer stem cell fractions promote stem like properties in the more vulnerable tumor cell populations2024