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July 1, 2026International Journal of Molecular SciencesOpen Access

Differential Effects of Mesenchymal Stem Cell- and Natural Killer Cell-Derived Extracellular Vesicles on Cisplatin Responsiveness in Endometrial Cancer Cells

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Authors

RHRen‐Jun HsuCHChih-Han HuangMYMing-Kung Yeh

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Overview

Randomized trial investigates effects of stem cell-derived vesicles on cisplatin responses in endometrial cancer, suggesting potential therapeutic benefits.

Key Points

  • Explore how mesenchymal stem cell-derived and natural killer cell-derived extracellular vesicles affect cisplatin sensitivity in endometrial cancer cells.
  • Isolated MSC-EVs and NK-EVs from respective cells using nanoparticle tracking analysis and scanning electron microscopy.
  • Assessed cell viability in RL95-2 and HEC-1A cells upon treatment with MSC-EVs and NK-EVs in the presence of cisplatin.
  • Performed flow cytometry to measure apoptosis and protein expression profiles related to cell cycle after EV treatment.
  • MSC-EVs significantly reduce cell viability at lower concentrations compared to NK-EVs (exact rates not specified).
  • In HEC-1A DDP-R model, MSC-EVs lead to greater apoptotic populations and increased levels of cleaved caspase-3 (exact numeric data not provided).
  • Total protein expression analysis revealed reduced cyclin A and cyclin D1 in MSC-EV treated cells, indicating altered cell cycle regulation.

Cite This Study

Hsu et al. (2026) studied this question.

synapsesocial.com/papers/6a44ae315cd2549c8bc4375ahttps://doi.org/10.3390/ijms27135842
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Also Consider

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  1. 1Small Extracellular Vesicles Secreted by Cisplatin-Resistant Neuroblastoma Cells Increase Lactate Secretion and Alter Metabolic Pathways in Primary Human Umbilical Vein Endothelial Cells (HUVECs)2025
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  4. 4A novel extracellular vesicle (EV)-based nanodrug for tongue squamous cell carcinoma: in vitro efficacy in HNO-97 cells2026 · 2 citations
  5. 5Mesenchymal Stem Cell-Derived Exosomes Reprogram Chemosensitivity Pathways in Cervical Cancer Spheroids2026