August 15, 2025Deleted JournalOpen Access

Role of nuclear factor-κB (NFκB) in microglial polarization in correlation with neuroinflammatory mechanism at the hippocampal cornu ammonis (CA) 1 region after acute and chronic phase of global ischemic brain injury in rats

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Quasi-experimental study shows NF-κB's impact on microglial polarization in hippocampal ischemia, indicating neuroinflammatory pathways.

NF-κB is crucial for hippocampal injury following ischemic events, promoting M1 microglial polarization and neuroinflammation.
Significant increase in CD68 positive areas was observed in ischemic groups compared to controls, indicating active microglial involvement.
Observed mRNA expression changes in IL1β, IL6, and TNFα underscore NF-κB's role in amplifying neuroinflammatory responses.
Findings highlight a significant correlation between NF-κB and microglial activation across acute to chronic phases of ischemic brain injury.

Wibisono et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

August 15, 2025Deleted JournalOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Quasi-experimental study shows NF-κB's impact on microglial polarization in hippocampal ischemia, indicating neuroinflammatory pathways.

NF-κB is crucial for hippocampal injury following ischemic events, promoting M1 microglial polarization and neuroinflammation.
Significant increase in CD68 positive areas was observed in ischemic groups compared to controls, indicating active microglial involvement.
Observed mRNA expression changes in IL1β, IL6, and TNFα underscore NF-κB's role in amplifying neuroinflammatory responses.
Findings highlight a significant correlation between NF-κB and microglial activation across acute to chronic phases of ischemic brain injury.

Wibisono et al. (2025) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark