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August 15, 2025Journal of the American Academy of Orthopaedic Surgeons

Evidence for Systemic Perioperative Antibiotic Prophylaxis for Prevention of Fracture-related Infections Following Open Fractures: Systematic Review and Meta-Analysis of Randomized, Controlled, Clinical Trials

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Authors

KKKevin M. KliftoCKChristopher S. KliftoSMSuhail K. Mithani

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Overview

Systematic review found clear guidelines for antibiotic use to prevent infection in open fractures, suggesting best practices.

Key Points

  • Systemic antibiotic prophylaxis reduces fracture-related infections following open fractures, and improves outcomes significantly.
  • Analysis of 21 randomized controlled trials provides strong evidence for effective antibiotic regimens after specific Gustilo-Anderson fracture types.
  • Meta-analysis of randomized controlled trials highlights the importance of guidelines in antibiotic prophylaxis protocols for open fractures.
  • Further research is needed to confirm these findings across different healthcare settings and fracture types.

Cite This Study

Klifto et al. (2025) studied this question.

synapsesocial.com/papers/68af5f0dad7bf08b1eae194bhttps://doi.org/10.5435/jaaos-d-24-00961
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Also Consider

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  3. 3Monotherapy Antibiotic Prophylaxis of Lower Extremity Long Bone Type III Open Fractures2024 · 3 citations
  4. 4Trends in the Use of Antibiotics for Open Forearm Fractures in Pediatric Patients from 2015 to 20232026
  5. 5Paediatric type I open tibia fractures: are antibiotics alone sufficient?2025