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October 2, 2025Open Access

Meta-Analysis of Acute Systemic Antimicrobial Prophylaxis (ASAP) for Open Extremity Fracture Management: Subgroup Analysis and Methodological Guidelines

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Authors

NGNicole A. GriffinAEAaron B. EppersonMAMohamed E. Awad

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Overview

Meta-analysis identifies infection rate comparisons and highlights methodological guidelines for open fractures.

Key Points

  • Flucloxacillin + Benzylpenicillin showed a lower infection rate than Cefazolin + Gentamicin in Type III open fractures.
  • Analysis involved 17 studies with 2,031 patients, focusing on infection rates and hospitalization duration.
  • No single antibiotic prophylactic regimen was determined superior for managing open fractures based on current data.
  • Methodological guidelines were proposed to enhance the robustness of future studies on antimicrobial prophylaxis.

Cite This Study

Griffin et al. (2025) studied this question.

synapsesocial.com/papers/68de84bb5b556a9128e1b9c2https://doi.org/10.20944/preprints202509.2480.v1
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