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August 25, 2025European Journal of Clinical NutritionOpen Access

Effects of orally administered cetylated fatty acids on symptoms and functional capacity in patients with knee osteoarthritis: results of a randomized, double-blind, placebo-controlled study

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Authors

MZManana ZodelevaLifeline HospitalNPNino PochkhuaGeorgian Technical UniversityMRMaria Sole RossatoAbiogen Pharma (Italy)

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Overview

Randomized, placebo-controlled trial shows CFA improves pain and range of motion in knee osteoarthritis patients.

Key Points

  • The CFA group experienced a significant pain reduction of -1.7 cm compared to placebo's -0.6 cm.
  • After 60 days, range of motion improvements favored CFA, showing a flexion increase of 3.8° and 2.9° in external rotation.
  • A total of 60 patients with knee osteoarthritis participated, with 1.5g of oral CFA administered daily over 60 days.
  • CFA supplementation resulted in a favorable safety profile, with only 4 patients reporting mild adverse events.

Cite This Study

Zodeleva et al. (2025) studied this question.

synapsesocial.com/papers/68af5f0dad7bf08b1eae1befhttps://doi.org/10.1038/s41430-025-01656-4
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