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August 25, 2025BMC GastroenterologyOpen Access

MAFLD outperforms NAFLD in identifying metabolic dysfunction in U.S. adolescents: a NHANES 2017–2020 analysis

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Authors

YZYigui ZouYDYu DaiHCHu Chen

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Overview

Cross-sectional analysis highlights MAFLD's superior identification of metabolic dysfunction in adolescents, suggesting improved clinical outcomes.

Key Points

  • MAFLD demonstrates significantly greater metabolic severity compared to NAFLD, indicating its clinical utility.
  • Prevalence of MAFLD was 22.8%, while NAFLD was slightly higher at 25.8% in U.S. adolescents with metabolic concerns.
  • LASSO regression revealed obesity as a shared risk factor, with MAFLD showing a more complex metabolic signature.
  • Multivariate logistic regression confirmed stronger associations with metabolic abnormalities for MAFLD over NAFLD.

Cite This Study

Zou et al. (2025) studied this question.

synapsesocial.com/papers/68af5f13ad7bf08b1eae1e6dhttps://doi.org/10.1186/s12876-025-04170-w
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