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August 25, 2025Open Access

Local Entropy in Proteins

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Authors

PSPatrick SenetAGAdrien GuzzoPDPatrice Delarue

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Overview

Local entropy categorizes unfolding in proteins, highlighting temperature effects and mutations, indicating broad implications.

Key Points

  • Local entropy shows significant shifts near melting points of proteins, defining distinct unfolding categories.
  • Average local entropy in gpW drastically changes near its melting point, offering insights into structural complexity.
  • Molecular dynamics simulations reveal that local entropy in α-synuclein varies significantly at physiological temperatures, resembling gpW.
  • Temperature impacts how proteins reshape and how mutations affect conformational ensembles, suggesting broad applications beyond protein science.

Cite This Study

Senet et al. (2025) studied this question.

synapsesocial.com/papers/68af5f13ad7bf08b1eae1f71https://doi.org/10.26434/chemrxiv-2025-qcd4w-v2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Local Entropy in Proteins2025 · 1 citations
  2. 2Making sense of chaos: uncovering the mechanisms of conformational entropy2024 · 5 citations
  3. 3Making sense of chaos: uncovering the mechanisms of conformational entropy2024 · 2 citations
  4. 4Protein Folding and the Minimum Rate of Entropy Production2026
  5. 5An analysis method of local entropy changes from atomic fluctuations.2026