Composites Based on Magnesium-Substituted Hydroxyapatite and Polysaccharides

Magnesium-substituted hydroxyapatites (Mg-HA) were synthesized in the presence of a chitosan or chitin polymer matrix by the aqueous solution method. The compounds obtained were studied for phase, spectroscopic and thermal properties. It was found that all the samples have identical morphologies. The results of cytotoxicity tests using the MTT assay revealed low effects of the samples on the cultured cells. The cell viability improved with a longer period of incubation. The composites that dissolve in physiological solutions with a medium rate have a stable positive effect on cells. The composites obtained are promising as non-toxic materials for the acceleration of implant bioresorption, which takes place with the participation of osteoclasts in vivo.