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August 26, 2025Frontiers in NeurologyOpen Access

Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies

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Retrospective analysis shows higher disability in NMOSD patients with anti-CTD Abs and ATAbs, indicating the need for targeted therapies.

Patients with positive anti-CTD Abs exhibited higher relapse rates and greater disability scores over 180 days.
Analysis revealed that double-positive patients had the highest levels of disability, with significant impacts from antibody combinations.
Retrospective analysis focused on NMOSD inpatients, utilizing clinical data across multiple antibody status groups within 180 days.
Routine antibody screening may help identify high-risk patients, facilitating more aggressive treatment strategies.

Liu et al. (2025) studied this question.

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