IL12-based phototherapeutic nanoparticles through remodeling tumor-associated macrophages combined with immunogenic tumor cell death for synergistic cancer immunotherapy

Jinyang Zhang; Wenyue Gao; Guilei Ma

doi:10.1039/d5bm00848d

January 1, 2025Biomaterials Science

IL12-based phototherapeutic nanoparticles through remodeling tumor-associated macrophages combined with immunogenic tumor cell death for synergistic cancer immunotherapy

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Key Points

Phototherapeutic nanoparticles enhanced tumor-associated macrophage reprogramming, improving cancer responses.
This approach shows synergy between IL12 and immunogenic tumor cell death, leading to stronger immune activation.
Utilizing nanoparticle technology enables targeted delivery to macrophages and facilitates effective reprogramming.
This method proposes a novel strategy for cancer treatment, highlighting the importance of macrophages in tumor response.

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Implication

IL12-based nanoparticles reprogram tumor-associated macrophages for synergistic cancer immunotherapy, indicating improved efficacy.

Abstract

Various cancer therapeutic strategies have been designed for targeting the tumor-associated macrophages (TAMs), but TAMs reprogramming-based monotherapy is often clinically hindered, likely due to the lack of a coordinated platform...

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af61fdad7bf08b1eae2acf https://doi.org/10.1039/d5bm00848d

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IL12-based phototherapeutic nanoparticles through remodeling tumor-associated macrophages combined with immunogenic tumor cell death for synergistic cancer immunotherapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

IL12-based phototherapeutic nanoparticles through remodeling tumor-associated macrophages combined with immunogenic tumor cell death for synergistic cancer immunotherapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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