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August 26, 2025MoleculesOpen Access

A Novel Aptamer Selection Strategy for Pseudomonas aeruginosa and Its Application as a Detecting Probe in a Hybrid Lateral Flow Assay

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Authors

TPThu Thao PhamNHNguyễn Thị HuyềnLOLe Hong Oanh

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Overview

Novel approach identifies aptamers for Pseudomonas aeruginosa, demonstrating high specificity in lateral flow assays.

Key Points

  • The aptamer T1 showed a visual detection limit of 2.34 × 102 CFU/mL in just 15 minutes, showcasing remarkable speed.
  • In this whole-cell approach, a new SELEX method facilitated recovering bound aptamers directly from bacterial cells.
  • Molecular docking analysis indicated that aptamer T1 had superior target selectivity compared to others during selection.
  • This innovative hybrid lateral flow assay enhances the potential for rapid point-of-care detection of bacterial pathogens.

Cite This Study

Pham et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2d41https://doi.org/10.3390/molecules30173499
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