Amlodipine and atenolol poisoning - A race against time for physicians

A fixed-dose combination (FDC) of amlodipine and atenolol is a commonly used antihypertensive drug that is often found in households. However, when taken in high doses, this medication can lead to serious and potentially fatal complications such as refractory hypotension, bradycardia and non-cardiogenic pulmonary oedema. We report the case of a 27-year-old male who attempted suicide by overdosing on this FDC due to a depressive episode. The patient presented with altered sensorium, refractory hypotension and bradycardia. Fortunately, prompt and intensive therapy with inotropes, calcium gluconate, intravenous fluids, high-dose insulin in dextrose and glucagon led to his recovery. This case highlights the potential dangers of a seemingly simple yet day-to-day antihypertensive medication and the importance of being aware of its potential risks.