Key result
Combination therapy including inotropes, insulin, and hemodialysis markedly improves hemodynamics in a case of amlodipine overdose.
Why the study?
Treatment of patients with amlodipine overdose remains challenging and existing information is limited to case reports and series.
Does a combination of fluids, inotropes, calcium, insulin, mechanical ventilation, and hemodialysis improve hemodynamics in a patient with severe amlodipine overdose?
Case Report (n=1)
Does a combination of fluids, inotropes, calcium, insulin, mechanical ventilation, and hemodialysis improve hemodynamics in a patient with severe amlodipine overdose?
A combination of fluids, inotropes, low-dose calcium, low-dose insulin, mechanical ventilation, and hemodialysis successfully treated severe amlodipine overdose.
Supports multimodal resuscitation in severe amlodipine overdose; hypothesis-generating and requires prospective trials before practice change.
Treatment of patients with amlodipine overdose remains challenging. We describe a case of successful treatment of refractory hypotension, noncardiogenic pulmonary edema and acute kidney injury after an intoxication with 250 mg of amlodipine. Marked improvement in all hemodynamic parameters was noted with combination of fluids, inotropes, low-dose calcium, low dose insulin, mechanical ventilation and hemodialysis. All available information on overdose of amlodipine is limited to case reports and series. Prospective trial on the use of these agents is required to define its role as the first-line treatment in amlodipine, a calcium channel blockers overdose.
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Kute et al. (2011) conducted a case report in Amlodipine overdose (n=1). Combination of fluids, inotropes, low-dose calcium, low dose insulin, mechanical ventilation and hemodialysis was evaluated on Hemodynamic parameters. Combination therapy with fluids, inotropes, low-dose calcium, low-dose insulin, mechanical ventilation, and hemodialysis resulted in marked improvement of hemodynamic parameters in amlodipine overdose.
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