Key result
A 0.1 mg IV phenylephrine bolus improves refractory hypotension in a severe amlodipine overdose case.
Why the study?
Does phenylephrine improve refractory hypotension in a patient with amlodipine overdose?
Case Report (n=1)
Does phenylephrine improve refractory hypotension in a patient with amlodipine overdose?
Phenylephrine may be effective for treating refractory hypotension in amlodipine overdose, though caution is required as it may exacerbate pulmonary edema.
Phenylephrine may offer rescue in refractory amlodipine overdose hypotension; single-case evidence leaves open broader validation.
Amlodipine is a commonly prescribed antihypertensive drug. We present a case of a young woman with a 70 mg amlodipine overdose admitted to our hospital with refractory hypotension and noncardiogenic pulmonary edema. She was initially managed in the intensive care unit (ICU) with intravenous sodium chloride 0.9% fluid boluses, calcium gluconate, and norepinephrine infusion, with poor response to therapy. After receiving phenylephrine 0.1 mg intravenous bolus, the patient showed improvement in blood pressure but experienced clinical worsening of pulmonary edema, which was subsequently managed with oxygen and furosemide therapy. With gradual clinical improvement, the patient was successfully discharged home on the fifth day. This case highlights that phenylephrine may be the drug of choice to treat refractory hypotension in amlodipine overdose without pulmonary edema.
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Samina et al. (2025) conducted a case report in Amlodipine overdose (n=1). Phenylephrine was evaluated on Blood pressure improvement. Administration of a 0.1 mg intravenous bolus of phenylephrine improved refractory hypotension from 90/40 mmHg to 110/70 mmHg within 1 hour in a patient with severe amlodipine overdose.
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