Key result
Amlodipine overdose linked to non-cardiogenic pulmonary edema and diffuse alveolar hemorrhage requiring mechanical ventilation.
Why the study?
Amlodipine overdose can cause severe complications, but diffuse alveolar hemorrhage as a complication had not been previously reported.
Case Report (n=1)
This represents the first reported case of diffuse alveolar hemorrhage complicating an amlodipine overdose.
Diffuse alveolar hemorrhage may complicate amlodipine overdose; first case leaves open its incidence and clinical vigilance needs.
A young adult female presented with hypotension and depressed mental status after intentional overdose of Amlodipine. After intubation and institution of lung-protective mechanical ventilation, initial management focused on maintenance of a mean arterial blood pressure over 65 mmHg and included fluid resuscitation (eight liters of crystalloid), Insulin and dextrose, intravenous calcium and, finally, vasopressor support. Her course was complicated by hypoxia due to non-cardiogenic pulmonary edema requiring diuresis. She was extubated soon thereafter but developed severe hypoxia within 72 hours requiring re-intubation. A subsequent bronchoscopy demonstrated diffuse alveolar hemorrhage (DAH). This is the first report of DAH complicating amlodipine overdose.
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Bringgold et al. (2022) conducted a case report in Amlodipine overdose (n=1). Amlodipine overdose was evaluated on Diffuse alveolar hemorrhage and non-cardiogenic pulmonary edema. Intentional amlodipine overdose in a young adult female was complicated by non-cardiogenic pulmonary edema and diffuse alveolar hemorrhage requiring mechanical ventilation.
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