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This article summarizes ctDNA methylation detection methods and analyzes affinity enrichment and Em-seq in cancer screening.
CtDNA methylation detection technology, as a novel tumor marker detection method, plays a significant role in cancer screening. This article summarizes the development history of ctDNA methylation detection technology, existing ctDNA methylation detection technology, and practical application cases of ctDNA methylation detection technology in cancer screening. It also analyzes the technical principles of two major existing techniques: affinity enrichment and Em-seq, as well as their respective advantages and disadvantages.
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Zekai Zhao (2025) studied this question.
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