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August 26, 2025Frontiers in Veterinary ScienceOpen Access

Baicalin-copper complex alleviates intestinal damage in avian pathogenic Escherichia coli-infected chicks by targeting the AKT/NF-κB pathway

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Authors

PCPanpan CaoJWJiazhen WeiXCXinyi Cheng

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Overview

Experimental analysis reveals that baicalin-copper complex reduces intestinal damage in chicks, suggesting potential for poultry health.

Key Points

  • BCU reduced diarrhea and mortality rates in APEC-infected chicks, achieving a mortality rate of only 7%.
  • The treatment significantly increased mRNA expression of intestinal barrier proteins, improving gut integrity and function.
  • Observational analysis showed BCU inhibited AKT/NF-κB signaling, modulating both oxidative stress and inflammation.
  • These findings highlight BCU's dual role as an antioxidant and an anti-inflammatory agent, benefiting poultry health.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68af63ddad7bf08b1eae4197https://doi.org/10.3389/fvets.2025.1648736
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