What question did this study set out to answer?

To evaluate the protective efficacy and molecular mechanism of baicalin pretreatment against avian pathogenic Escherichia coli (APEC)-induced intestinal barrier damage and inflammation in chicks.

October 29, 2021SHILAP Revista de lepidopterologíaOpen Access

Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway

View Full Paper

Ask AI

Bookmark

Authors

XCXinyi ChengLuohe Medical College ZCZhanyou CaoJiangxi Agricultural University JLJunrong LuoPeking University

Discussion

Member takes

Implication

Randomized animal trial reveals baicalin reduces gut damage and inflammation in chicks challenged with pathogenic E. coli, highlighting its therapeutic potential for avian colibacillosis.

Key Points

To evaluate the protective efficacy and molecular mechanism of baicalin pretreatment against avian pathogenic Escherichia coli (APEC)-induced intestinal barrier damage and inflammation in chicks.
Sixty 1-day-old chicks were randomly assigned to 4 groups (N=60): control, APEC infection alone, 10 mg/kg baicalin, and 20 mg/kg baicalin.
Chicks received daily oral baicalin pretreatment for 15 days before pectoralis injection with APEC, followed by ileal tissue harvest and molecular analysis.
Baicalin pretreatment reduced diarrhea rates, chick mortality, and intestinal histopathology while increasing mRNA and protein expressions of tight junction components (ZO-1, Claudin1, Occludin) and antimicrobial peptides.
Baicalin augmented antioxidant enzyme activity (T-SOD, CAT, GSH-Px), diminished lipid peroxidation marker MDA, and suppressed proinflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8).
Infection-induced activation of the PI3K/AKT and NF-κB pathways was markedly inhibited by baicalin through downregulation of total and phosphorylated protein levels.

Cite This Study

Cheng et al. (2021) studied this question.

synapsesocial.com/papers/69d75c3ef182769aa8b8aa1c https://doi.org/10.1016/j.psj.2021.101572

View Full Paper

Ask AI

Bookmark

Implication

Randomized animal trial reveals baicalin reduces gut damage and inflammation in chicks challenged with pathogenic E. coli, highlighting its therapeutic potential for avian colibacillosis.

Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider