What type of study is this?

This is a In Vitro Study study (also classified as: Animal Study).

August 26, 2025Open Access

Icariin Attenuates Atherosclerosis via TNF/AKT/IL-6 Signaling Axis: Insights from Network Pharmacology and Experimental Validation in RAW264.7 Macrophages and ApoE −/− Mice

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Authors

JSJianshu SongChinese Academy of Medical Sciences & Peking Union Medical College CCCe CaoXiyuan Hospital ZLZixin LiuMinzu University of China

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Implication

Experimental validation and network pharmacology analysis demonstrate icariin's ability to reduce atherosclerosis in mice, indicating multi-target therapeutic potential.

Key Points

Icariin significantly reduced aortic arch thickness and plaque area in ApoE−/− mice, showcasing its anti-atherosclerotic effect.
Key targets like TNF, AKT1, and IL-6 were identified, with icariin showing strong binding affinity to them during analysis.
Network pharmacology and in vitro experiments with RAW264.7 macrophages revealed that icariin inhibits foaming and regulates key signaling pathways.
These findings support the notion that icariin may offer a safer and more effective treatment for atherosclerosis compared to existing therapies.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/68af63e3ad7bf08b1eae425f https://doi.org/10.21203/rs.3.rs-7377505/v1

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Implication

Experimental validation and network pharmacology analysis demonstrate icariin's ability to reduce atherosclerosis in mice, indicating multi-target therapeutic potential.

Icariin Attenuates Atherosclerosis via TNF/AKT/IL-6 Signaling Axis: Insights from Network Pharmacology and Experimental Validation in RAW264.7 Macrophages and ApoE −/− Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Icariin Attenuates Atherosclerosis via TNF/AKT/IL-6 Signaling Axis: Insights from Network Pharmacology and Experimental Validation in RAW264.7 Macrophages and ApoE −/− Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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