What is the clinical evidence from this study?

Study design: Other. Population: Hyperlipidemia and atherosclerosis. Intervention: Icariin. Primary outcome: Serum lipid levels, atherosclerotic burden, and hemorheological parameters.

What does this research mean for the field?

Icariin reduces serum cholesterol levels, decreases atherosclerotic burden, and attenuates the prothrombotic state by improving hemorheological parameters and platelet activation in hypercholesterolemic rabbits. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 22, 2013Planta Medica

Icariin Attenuates the Enhanced Prothrombotic State in Atherosclerotic Rabbits Independently of Its Lipid-Lowering Effects

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Key result

Icariin reduces LDL cholesterol and atherosclerotic burden in rabbits on a high-cholesterol diet.

Authors

WZWeiping ZhangFujian University of Traditional Chinese Medicine XBXiaojun BaiShanghai Jiao Tong University XZXiaopu ZhengKansai Medical University

Discussion

Member takes

Implication

Hypothesis-generating for icariin in atherosclerosis; should not yet change clinical practice.

PICO

Population

Rabbits fed a high-cholesterol diet to induce hyperlipidemia and atherosclerosis.

Intervention / Comparator

Icariin

Primary Outcome

Serum lipid levels, atherosclerotic burden, and hemorheological parameters

Cite This Study

Zhang et al. (2013) studied Hyperlipidemia and atherosclerosis. Icariin was evaluated on Serum lipid levels, atherosclerotic burden, and hemorheological parameters. Icariin reduced serum total and LDL cholesterol, decreased atherosclerotic burden, and improved hemorheological parameters and platelet activation in rabbits fed a high-cholesterol diet.

synapsesocial.com/papers/6aa93e809be60f56210dfec0 https://doi.org/10.1055/s-0032-1328551

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Icariin Attenuates the Enhanced Prothrombotic State in Atherosclerotic Rabbits Independently of Its Lipid-Lowering Effects

Discussion

Member takes

Implication

PICO

Cite This Study

Icariin Attenuates the Enhanced Prothrombotic State in Atherosclerotic Rabbits Independently of Its Lipid-Lowering Effects

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider