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November 1, 2021Biochemistry (Moscow)

Icariin (100-200 mg/kg) attenuated NAFLD-induced increases in TG, TC, LDL-C, ALT, and AST, and improved glucose tolerance and insulin sensitivity, effects that were reversible by the AMPK inhibitor dorsomorphin.

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Why the study?

Non-alcoholic fatty liver disease is the most common liver disease worldwide, but the therapeutic activity of icariin in NAFLD remains unknown.

Does icariin improve hyperlipidemia-induced NAFLD and lipid metabolism disorders in a high-fat diet mouse model?

Population

C57BL/6J mice fed a high-fat diet for 16 weeks

Comparison

Control vs NAFLD vs icariin treatment with or without dorsomorphin

Design

Preclinical animal study

Authors

YJYin JinXHXiang HuEHErjiong Huang

Discussion

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Overview

Preclinical icariin effects in mouse NAFLD leave open human translation; should not yet inform clinical practice.

Structured PICO

Does icariin improve hyperlipidemia-induced NAFLD and lipid metabolism disorders in a high-fat diet mouse model?

P
Population
C57BL/6J mice fed with a high-fat diet for 16 weeks to establish a non-alcoholic fatty liver disease (NAFLD) model
I
Intervention
Icariin treatment (100-200 mg/kg) with or without AMPK inhibitor dorsomorphin
C
Comparator
Control group and untreated NAFLD group
O
Outcome
Blood indices (TG, TC, LDL-C, HDL-C, ALT, AST), glucose tolerance, insulin sensitivity, histopathological morphology, cell apoptosis, lipid accumulation, and AMPK signalingsurrogate

Icariin demonstrates glucose-reducing and lipid-lowering effects in a mouse model of NAFLD, likely mediated through the AMPKα1/PGC-1α/GLUT4 pathway.

Cite This Study

Jin et al. (2021) studied this question.

synapsesocial.com/papers/6a8293f3abc87fc4bf1e0f9chttps://doi.org/10.1134/s0006297921110055
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