Why the study?
Interruptins A and B exhibit anti-diabetic, anti-inflammatory, and anti-oxidative effects, but the therapeutic ability and mechanisms of an interruptin-enriched Cyclosorus terminans extract in obese rats remained to be investigated.
Does extract enriched by interruptins A and B (EEI) from Cyclosorus terminans improve insulin resistance and NAFLD in HFD-induced obese rats?
Population
High-fat diet-induced obese rats
Comparison
Extract enriched by interruptins A and B (EEI) treatment
Design
Animal study
Follow-up
2 weeks
Authors
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Hypothesis-generating for interruptins in obesity-related metabolic disease; prospective human studies needed before clinical adoption.
Does extract enriched by interruptins A and B (EEI) from Cyclosorus terminans improve insulin resistance and NAFLD in HFD-induced obese rats?
Extract enriched by interruptins A and B from Cyclosorus terminans ameliorates HFD-induced insulin resistance and NAFLD in rats by modulating insulin signaling, inflammation, and lipid metabolism pathways.
Songtrai et al. (2022) studied this question.
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