Copper-Catalyzed Oxy-Alkylation of Styrenes Enabled by Halogen-Atom Transfer

Qiujian Tan; Xiang Lyu; Yu Zhao; Huaquan Fang; Xianxiu Xu; Zhongyan Hu

doi:10.1039/d5sc03774c

January 1, 2025Chemical ScienceOpen Access

Copper-Catalyzed Oxy-Alkylation of Styrenes Enabled by Halogen-Atom Transfer

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Key Points

The method enables the difunctionalization of styrenes by incorporating oxygen and alkyl groups, enhancing synthetic versatility.
Key evidence indicates that utilizing copper catalysis allows for effective halogen-atom transfer under air-equilibrated conditions.
This approach integrates α-aminoalkyl radical-mediated halogen-atom transfer with copper catalysis, providing a distinct mechanistic pathway.
The findings highlight the potential of copper catalysis in developing innovative methods for complex organic synthesis.

Implication

This approach demonstrates dibunctionalization of styrenes with alkyl halides and oxygen, implying novel catalytic mechanisms.

Abstract

Herein, we present a mechanistically distinct approach to the multicomponent difunctionalization of styrenes with alkyl halides and oxygen by integrating α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with copper catalysis under air-equilibrated...

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Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/68af63e3ad7bf08b1eae4356 https://doi.org/10.1039/d5sc03774c

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Copper-Catalyzed Oxy-Alkylation of Styrenes Enabled by Halogen-Atom Transfer

Key Points

Implication

Abstract

Discussion

Cite This Study

Copper-Catalyzed Oxy-Alkylation of Styrenes Enabled by Halogen-Atom Transfer

Key Points

Implication

Abstract

Discussion

Cite This Study

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