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Copper-catalyzed radical alkylarylation improves diarylalkane synthesis, suggesting efficient methods for pharmaceutical development.
The radical-initiated 1,2-alkylarylation of styrenes provides a step-economic strategy for the expedient synthesis of pharmaceutically valuable 1,1-diarylalkane scaffolds. We herein report a copper-catalyzed radical 1,2-alkylarylation of styrenes using easily available alkyl halides and arylboronic esters under mild thermal conditions. The employment of a multidentate anionic N,N,N-ligand is crucial for facilitating this transformation with high efficiency.
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Luo et al. (2026) studied this question.
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