Photocatalytic Deacylative 1,2-Alkyl(hetero)arylation of Electron-Rich Styrenes

We report a mild photoredox-catalyzed deacylative three-component 1,2-alkyl(hetero)arylation of electron-rich styrenes with unstrained ketone-derived dihydroquinazolinones and electron-rich (hetero)arenes, showcasing high substrate compatibility under oxidative conditions. The radical–polar crossover blueprint uniquely integrates deacylative radical C(sp3)–C(sp3) bond formation with polar electrophilic aromatic substitution (SEAr)-driven C(sp3)–C(sp2) bond construction, overcoming competitive N-alkylation and E1-elimination. This method mostly offers a direct route to 1-aryl-1′-heteroarylalkanes and unsymmetrical 1,1-bis(heteroaryl)alkanes.