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August 25, 2025Journal of Clinical MedicineOpen Access

Revealing New Trends in the Global Burden of Hepatocellular Cancer Related to Hepatitis C Virus by Region, Sociodemographic Index, and Sex

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Authors

LSLynette M. SequeiraXYXiaohan YingNÖNazlı Begüm Öztürk

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Overview

Analysis shows rising HCV-related hepatocellular cancer deaths globally, indicating diverse regional healthcare challenges.

Key Points

  • Deaths and disability-adjusted life years from hepatitis C-related hepatocellular cancer are increasing globally, highlighting urgent public health needs.
  • The Americas saw the highest annual percent change in all metrics, driven by aging populations and better detection rates.
  • Joinpoint regression modeling was performed on GBD 2021 data to analyze trends by WHO region and sociodemographic index over three decades.
  • High-sociodemographic index regions showed favorable trends post-2016, emphasizing the impact of direct-acting antivirals and WHO initiatives.

Cite This Study

Sequeira et al. (2025) studied this question.

synapsesocial.com/papers/68af63e9ad7bf08b1eae4882https://doi.org/10.3390/jcm14176006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in hepatocellular carcinoma (HCC) incidence and impact of hepatitis C antiviral therapy: A population-based subgroup analysis.2026 · 1 citations
  2. 2Global trends in hepatitis C-related hepatocellular carcinoma mortality: A public database analysis (1999-2019)2024 · 14 citations
  3. 3Global, regional, and National burden of hepatitis C from 1990 to 2021 and projections until 20302025 · 6 citations
  4. 4Changing global epidemiology of chronic hepatitis C virus-related outcomes from 2010 to 2019: cirrhosis is the growing burden of hepatitis C virus-related disease2024 · 6 citations
  5. 5Abstract 3679: Trends and disparities in hepatitis C virus-associated hepatocellular carcinoma mortality in the United States, 1999-20232026