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August 26, 2025Journal of Pharmacy & Pharmaceutical SciencesOpen Access

Optimized Ginkgo biloba extract EGb 761®: boosted therapeutic benefits with minimized CYP enzyme interference

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Authors

SKSoon‐Jae KwonSJSuji JeongSLS.-Y. Lee

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Overview

Comparative analysis shows EGb 761 enhances cognitive benefits in drugs while minimizing CYP enzyme interference.

Key Points

  • EGb 761 shows a greater cognitive enhancement effect due to higher protocatechuic acid content and unique composition.
  • CYP inhibition tests revealed lower interaction with drug metabolism for EGb 761 compared to other extracts.
  • Methods used include HPLC and LC-MS/MS to analyze extract compositions and molecular docking for binding affinity.
  • Lower CYP inhibition implies that EGb 761 may offer safer cognitive enhancement options, warranting further research.

Cite This Study

Kwon et al. (2025) studied this question.

synapsesocial.com/papers/68af63efad7bf08b1eae4ab9https://doi.org/10.3389/jpps.2025.14614
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