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August 26, 2025International Journal of Surgical Pathology

Spectrum of Histopathologic Findings in Transgender Men Undergoing Gender-Affirming Gynecologic Surgery Following Preoperative Androgen Therapy: A Tertiary Care Center Study

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Authors

NBNeha BakshiBNBheem Singh NandaSRSeema Rao

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Overview

Findings illustrate histologic alterations in transgender men after androgen therapy, highlighting diagnostic implications for pathologists.

Key Points

  • Distinctive histologic alterations are present in transgender men post-surgery, showing significant changes due to androgen therapy.
  • Seventy-five percent of the endometrial samples were histologically inactive, with prominent changes indicating androgen exposure.
  • Assessment of histopathology from transgender men undergoing gynecologic surgery shows substantial cystic follicle development in ovaries.
  • These findings suggest the need for heightened awareness among pathologists to avoid diagnostic errors when interpreting similar samples.

Cite This Study

Bakshi et al. (2025) studied this question.

synapsesocial.com/papers/68af63efad7bf08b1eae4bfdhttps://doi.org/10.1177/10668969251363990
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