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September 5, 2025New England Journal of Medicine
Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction
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Implication
Randomized trial shows no significant differences in outcomes with beta-blocker therapy after myocardial infarction, indicating treatment may not benefit patients with normal ejection fraction.
Key Points
- Beta-blocker therapy showed no effect on death or reinfarction rates after myocardial infarction.
- During 3.7 years follow-up, outcomes were similar with 11.2 vs. 10.5 death events per 1000 patient-years in each group.
- The study included 8438 patients to investigate the efficacy of beta-blocker therapy versus no therapy.
- Findings suggest that beta-blockers may not be necessary for patients with a left ventricular ejection fraction above 40%.
Cite This Study
Ibáñez et al. (2025) studied this question.