Keeping Up With Carney Complex

Carney complex (CNC) is a rare genetic disorder characterized by endocrine and nonendocrine tumors, including cardiac myxomas, which are a leading cause of mortality due to embolic events, arrhythmias, heart failure, and sudden cardiac death. We present the case of a 33-year-old man with CNC who experienced stroke-like symptoms due to recurrence of a left atrial myxoma 10 years after initial resection. He underwent successful surgical resection. Cardiac myxoma recurrence is higher in patients with CNC, with rates up to 22% compared with 2% to 3% in sporadic cases. This case underscores the importance of lifelong, multidisciplinary care and rigorous surveillance to prevent severe cardiovascular complications. Although rare, it is important to recognize the clinical features and complications of CNC, including the increased risk of recurrent cardiac myxomas. Lifelong cardiac imaging is recommended at 6- to 12-month intervals in patients with CNC.