TTP2.06 Predictors of Advanced Stage and Emergency Presentation in Colorectal Cancer Patients in Central Scotland

Aims To determine which factors were associated with and predictive of an advanced stage at diagnosis and emergency mode of presentation in colorectal cancer patients. Methods Data were collected on 587 consecutive patients discussed at multidisciplinary team meetings between January 2017 and December 2019 at an acute hospital in Scotland. The effect of variables on stage and mode of presentation was analysed using logistic regression. Results 55.4% of patients had advanced (stage III or IV) disease and 19.7% presented as an emergency. Patients presenting as an emergency were more likely to have advanced disease (OR 1.64, 95%CI 1.02–2.62, p=0.04) compared to the 22.5% diagnosed at screening (OR 0.33, 95%CI 0.21–0.52, p<0.001). Individuals with affected first-degree relatives were more likely to present with advanced disease (OR 2.39, 95%CI 1.06–5.40, p=0.04). The association of deprivation and tumour site with advanced disease at presentation was significant (p=0.04 and p=0.013, respectively). The likelihood of presenting as an emergency increased with age (OR 1.03, 95%CI 1.01–1.05, p=0.003) and with advanced disease (OR 2.15, 95%CI 1.37–3.38, p<0.001). Again, the relationship between tumour site and emergency presentation was significant (p=0.002). Conclusions Socioeconomic status, mode of presentation, tumour site, and family history status were significant predictors of stage at presentation, whereas stage, tumour site and age were significantly associated with mode of presentation. Further work is required to increase screening uptake, particularly amongst high-risk groups, in order to detect disease at an early stage and reduce the number of patients presenting as emergencies.