WTP5.10 Managing Severe Radiotherapy-Induced Breast Change with Lipomodelling : A Case Report

Background Radiotherapy is a critical component of breast cancer treatment but can lead to severe complications, including fibrosis, volume loss, and chronic wounds. Lipomodelling or autologous fat grafting, has emerged as an effective solution for managing such complications. This case demonstrates the role of sequential lipomodelling in managing severe radiotherapy-induced breast changes. Case Summary A 71-year-old woman was diagnosed with grade 2 invasive papillary carcinoma in the right breast with two malignant lesions (Areas A and B) and a benign lesion (Area C). She underwent Right Breast wide local excision ×2 and sentinel lymph node biopsy followed by adjuvant radiotherapy. Post-radiotherapy, the patient developed severe skin reactions, including radiation burns, fibrosis, radiotherapy dermatitis, and a chronic ulcer on the lower pole of the right breast, necessitating inpatient care. Initial management included honey dressings and topical treatments; however, the chronic ulcer persisted. The patient was offered lipomodelling. The first procedure which resulted in complete ulcer healing, softer breast tissue, and reduced pain. A second procedure further improving contour, texture, and skin quality. Results • Complete healing of the chronic ulcer. • Significant improvement in breast softness and volume. • Reduced pain and marked enhancement of skin texture. Conclusion This case highlights the effectiveness of lipomodelling in managing severe radiotherapy-induced breast complications. The regenerative properties of adipose-derived stem cells promote healing, improve tissue quality, and restore breast aesthetics. Sequential procedures and multidisciplinary approaches, including the potential use of hyperbaric oxygen therapy, may optimize outcomes for similar cases.