TTP1.12 90-day mortality in colorectal cancer resections: A cohort study

Aims 90-day mortality remains low at 2.7 % (NBOCA 2024) after colorectal cancer resection. The aim of this study was to assess causes of early postoperative mortality. Methods A cohort study was carried out at a single institution from January 2007 to February 2025. Descriptive demography & post-operative outcomes were assessed for < 90 day deaths following colorectal cancer resections, deaths > 90-day deaths & alive colorectal resections were recruited as controls. Results 90-D mortality(n = 110) > 90-D mortality(n = 1754) Mann Whitney UP value Age (yrs) 75.9 ± 1.1 69.9 ± 0.3 < 0.0001 Sex (M:F) 68 : 42 962 : 792 NS ASA (median) 3 2 < 0.0001 Wt (kg) 70.2 ± 1.9 75.9 ± 0.5 0.002 BMI (kg/m2) 24.8 ± 0.6 26.6 ± 0.1 0.0056 Emergency (n) 61 330 < 0.0001 Laparoscopic (n) 50 1043 0.0130 Complications (n) Leaks 4 71 NS Ileus 20 271 NS HAP 24 172 0.0346 Wound infections 9 152 NS Collection 5 108 NS Sepsis 8 96 NS Operation time (mins) 125.1 ± 6.1 180.0 ± 2.1 < 0.0001 LOS (days ± IQR) 12 ± 9 8 ± 4 < 0.0001 Stage 4 disease 27 87 0.0006 Conclusion 90-day mortality reflects peri-operative mortality, which was 5.9 % at our institution. NBOCA has set local hospital targets at < 6 % for 90 day mortality. Emergency CRC resections, advanced disease, high risk patients were disproportionately higher amongst the < 90-days deaths. Pre-operative optimization & post operative ITU support may reduce complications & hospitalization. Palliative therapies should be offered early to advanced disease CRC resections.