Retrospective observational study evaluates surgical site infections related to antibiotic prophylaxis duration in neonates, revealing key risk factors.
To evaluate the relationship between the incidence of surgical site infections (SSIs) and the duration of perioperative antibiotic prophylaxis (PAP) in neonatal surgery, and to identify risk factors for SSIs in neonates. Eligible patients were neonates who underwent surgical procedures-primarily in the respiratory and gastrointestinal fields-between January 2014 and December 2023 at seven institutions. All data were retrospectively retrieved from electronic patient records. We estimated the risk difference using a modified least-squares regression model. Of the 983 patients included, 91 (9%) developed SSIs. A total of 735 patients (75%) received PAP for >24 h. There was no significant difference in risk when PAP duration was <24 h compared with ≥24 h. Independent risk factors for SSIs were an operative time exceeding 120 min, past surgical history, and open surgery. In neonatal surgery, a short duration (<24 h) of PAP may not increase the risk of SSI.
No takes yet. Share an insight, caveat, or question.
Sunouchi et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: