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September 5, 2025BMC GenomicsOpen Access

Integration of genome and transcriptome reveals core genes and allele-specific expression genetic variants associated with immune differentiation of taurine ancestry dairy cattle from indicine ancestry cattle

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Authors

QCQuanzhen ChenSCSiqian ChenYTYongjie Tang

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Overview

This research reveals allele-specific expression and immune gene variants in taurine versus indicine cattle, suggesting pathways for genomic selection.

Key Points

  • Taurine ancestry dairy cattle show distinct immune characteristics compared to indicine ancestry, with implications for health.
  • A total of 184 core immune genes and 1,255 allele-specific expression variants were identified, highlighting immune function differences.
  • Analysis used high-throughput omics data from liver and spleen tissues to construct immune and disease scores, assessing immunity.
  • Findings suggest potential candidate markers for enhancing immunity in dairy cattle through future genomic selection strategies.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d4e2b87ece8dc955a1ehttps://doi.org/10.1186/s12864-025-11936-9
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