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February 25, 2026

Genome-Wide Association Study of Leukocyte Traits Reveals Candidate Genes Associated With Immunity in Holstein Cattle From Southern China.

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Authors

CLChenhui LiuJYJie YuZZZhuxia Zhong

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Overview

Genome-wide association study uncovers genes affecting immunity in dairy cows, suggesting breeding improvements.

Key Points

  • The aim is to identify genetic sources of immune variation in Holstein cattle through leukocyte traits.
  • Measured leukocyte traits in 200 healthy Holstein cows
  • Conducted genome-wide association study (GWAS) on collected data
  • Analyzed single-nucleotide polymorphisms (SNPs) related to leukocyte counts
  • Identified 70 SNPs associated with leukocyte traits
  • 15 SNPs located within introns of genes
  • Highlighted BEND5 and FOXJ3 as candidate genes affecting white blood cell counts

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/699e91c4f5123be5ed04f899https://doi.org/10.1002/vms3.70858
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Also Consider

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  1. 1Identification of Candidate Variants Associated with Milk Production, Health and Reproductive Traits for Holstein Cows in Southern China2025 · 1 citations
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  3. 3Integration of genome and transcriptome reveals core genes and allele-specific expression genetic variants associated with immune differentiation of taurine ancestry dairy cattle from indicine ancestry cattle2025
  4. 4Genome-wide association study and fine-mapping using imputed sequences to prioritize candidate genes for 30 complex traits in 50,309 Holstein bulls2025
  5. 5Integrated selection scans and cis-eQTL analyses reveal genes and variants associated with milk quality, immunity, and adaptation in endangered Dengchuan cattle2026