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September 5, 2025Open Access

Early risk factors for metabolic dysfunction in young people with major mood disorders: Longitudinal path analysis of a prospective birth cohort using structural equation modelling.

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Authors

SMSarah McKennaMVMathew VaridelMSMirim Shin

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Overview

Longitudinal cohort study reveals correlations among sleep-wake disturbance, metabolic dysfunction, and mood disorders.

Key Points

  • A small correlation exists between depressive symptoms at age 21 and metabolic dysfunction at age 30.
  • The study found an indirect relationship where sleep-wake disturbance impacted metabolic outcomes linked to mood disorders.
  • Sleep-wake cycle disturbance appears to play a role in metabolic dysfunction, contrary to the focus on weight gain.
  • Findings indicate clinical populations need more precise measures of sleep-wake disturbances for accurate assessments.

Cite This Study

McKenna et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d4e2b87ece8dc955af9https://doi.org/10.1101/2025.08.24.25334329
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identifying pathways to early‐onset metabolic dysfunction, insulin resistance and inflammation in young adult inpatients with emerging affective and major mood disorders2021 · 22 citations
  2. 2Identifying mood disorder subgroups at early risk of metabolic dysfunction: a cross-sectional cohort study in young people at early intervention services.2025
  3. 3Increased metabolic risk in young people with emerging mood disorders and circadian rhythm disruption.2024 · 3 citations
  4. 4Uncovering relationships between 24-hour rest-activity patterns and immune-metabolic dysfunction in young people with mood disorders.2025
  5. 5Longitudinal trajectories of metabolic and inflammatory markers in youth with emerging mood disorders2024 · 3 citations