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September 5, 2025

Uncovering relationships between 24-hour rest-activity patterns and immune-metabolic dysfunction in young people with mood disorders.

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Authors

SMSarah McKennaMSMirim ShinSPShin Park

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Overview

Observational analysis reveals links between rest-activity patterns and immune-metabolic risk in young people, suggesting potential early intervention strategies.

Key Points

  • Higher intradaily variability in rest-activity patterns was linked to increased BMI and fasting insulin among participants.
  • Dampened circadian rhythms were correlated with higher BMI and immune markers only in those with full threshold mood disorders.
  • Increased moderate-to-vigorous physical activity was associated with lower BMI specifically in participants at Stage 2+.
  • These findings support the importance of stabilizing rest-activity rhythms for preventing metabolic dysfunction in mood disorder patients.

Cite This Study

McKenna et al. (2025) studied this question.

synapsesocial.com/papers/68bb42142b87ece8dc9584b3https://doi.org/10.1101/2025.08.26.24311025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased metabolic risk in young people with emerging mood disorders and circadian rhythm disruption.2024 · 3 citations
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  3. 3Early risk factors for metabolic dysfunction in young people with major mood disorders: Longitudinal path analysis of a prospective birth cohort using structural equation modelling.2025
  4. 4Identifying pathways to early‐onset metabolic dysfunction, insulin resistance and inflammation in young adult inpatients with emerging affective and major mood disorders2021 · 22 citations
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