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September 5, 2025

Design, Synthesis, Characterization and Biological Evaluation of Some Novel Heterocyclic Derivatives as Anti Tubercular Agents Targeting Inha (Enoyl Acyl Carrier Protein Reductase) Enzyme

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AAAnkita Anod Adhav

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Overview

Synthesis and biological evaluation of imidazole derivatives targeting inha enzyme shows promising anti-tubercular activity.

Key Points

  • Compound R2 exhibits strong anti-tubercular activity with a minimum inhibitory concentration (MIC) below 3.12 mcg/mL, demonstrating potential as a new treatment.
  • R4 and R6 show moderate anti-tubercular activity with MIC values below 12.5 mcg/mL, emphasizing the importance of imidazole derivatives in drug development.
  • The study utilized Microplate Alamar Blue Assay (MABA) to evaluate anti-mycobacterial activity against the tuberculosis H37RV strain.
  • This research highlights the urgent need for new drug development targeting drug-resistant tuberculosis strains.

Cite This Study

Ankita Anod Adhav (2025) studied this question.

synapsesocial.com/papers/68bb3d552b87ece8dc955f72https://doi.org/10.35629/4494-100410161062
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