Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025MoleculesOpen Access

Comparative Study of Ni(II) Complexes with Dithiocarbazate- and Thiosemicarbazone-Based Ligands: Synthesis, Crystal Structures, and Anticancer Activity

View Full Paper
Ask AI
Bookmark
Share

Authors

GPGabriel S. PessoaUniversidade de BrasíliaMVMarta VianaUniversidad San Pablo CEUKOKatia M. OliveiraUniversidade de Brasília

Discussion

Loading...

Member takes

Implication

This study demonstrates the anticancer activity of Ni(II) complexes in breast and ovarian cancer, indicating strong potential for new treatments.

Key Points

  • Cytotoxicity significantly enhanced in certain Ni(II) complexes compared to untreated cells.
  • Complex (2) showed superior cytotoxicity against MCF-7 and A2780cis, outperforming cisplatin.
  • Single-crystal X-ray diffraction revealed distorted square planar geometry in the complexes.
  • Biological assays were conducted on multiple cancer cell lines, showcasing varied efficacy against different types.

Cite This Study

Pessoa et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc9561d6https://doi.org/10.3390/molecules30173516
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A short history of SHELX2007 · 87,955 citations
  2. 2Molecular mechanisms of cisplatin resistance in ovarian cancer2023 · 27 citations
  3. 3Crystal Structures and Biological Profiles of Novel Tridentate Schiff Bases Nickel (II) Complexes2024 · 17 citations
  4. 4Synthesis and biological evaluation of salophen nickel(II) and cobalt(III) complexes as potential anticancer compounds2023 · 16 citations