August 15, 2025Baghdad Science JournalOpen Access

Synthesis, Characterization, and Anticancer Evaluation of Novel Nickel(II) and Copper(II) Complexes Derived from Isatin Thiosemicarbazones

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Discussion

Synthesis of nickel and copper complexes shows improved anticancer activity in MCF-7 cells, suggesting future therapeutic potential.

[Cu2(L)Cl2] showed higher cytotoxicity against MCF-7 cells than cisplatin, with an IC50 of 8.43 µM.
Both nickel and copper complexes demonstrated enhanced potency compared to existing anticancer drugs like cisplatin.
Synthesis involved novel ligand L derived from isatin thiosemicarbazones and metal chlorides, forming square planar complexes.
This research indicates the potential of these complexes for future cancer treatment advancements.

Shahnaz Abdulhamid Hamad (2025) studied this question.

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