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March 24, 2026Journal of Molecular StructureOpen Access

New N-Benzoylthiourea-pyrrolidine-based Copper(II) complexes as anticancer agents

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Authors

SPSamet PoyrazSBSamet BelverenHDH. Ali Döndaş

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Overview

Novel copper(II) complexes demonstrate potent anticancer activity in lung and colon cancer cells, suggesting potential therapeutic applications.

Key Points

  • The aim is to evaluate the anticancer properties of N-benzoylthiourea-pyrrolidine-based copper(II) complexes.
  • Synthesis and characterization of four novel copper(II) complexes.
  • Evaluation of cytotoxicity against various cancer cell lines including A549, MCF-7, and HCT116.
  • Molecular docking studies to analyze binding interactions with specific proteins.
  • Stability constants determined using potentiometric titration and HYPERQUAD modeling.
  • L3-Cu complex shows the strongest cytotoxicity against A549 cells with IC50 of 4.46 µM.
  • L3-Cu outperforms cisplatin (>100 µM for A549) with lower toxicity to normal cells.
  • Significant binding interactions observed with PI3K, HDAC6, JNK1, and ERα in different cancer cells.

Cite This Study

Poyraz et al. (2026) studied this question.

synapsesocial.com/papers/69c22982aeb5a845df0d41b7https://doi.org/10.1016/j.molstruc.2026.146046
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